4/19/2023 0 Comments Terrapin irest capsulesJeffery Hergenrather, President of the Society of Cannabis Clinicians, addressed the issue of cannabinoid ratios as follows: “Standardized testing is essential to the advancement of our understanding of this issue.” – Dr. However, given the emergence of CBD into the public consciousness, more people are considering cannabinoid ratios. Thus the typical products in your local dispensary will have THC:CBD ratios as high as 20:1 for flowers and 80:1 for concentrates. Additionally, historical patient demand has pushed cultivators to favor strains with higher THC. Due to federal prohibition in the US, the vast majority of cannabis is grown indoors. Practical Implications For Medical Marijuana PatientsĪs it stands, there is still an overwhelming trend towards favoring one cannabinoid over another. These two properties are critical to combating the spread of cancer within the body, making whole-plant cannabis extracts a viable medical option. Furthermore, THC and CBD each possess cytotoxic (cell destroying) and anti-angiogenic (prevention of development of new blood vessels) properties. In cancer, cannabis has long been credited with helping people combat the nausea associated with chemotherapy. Recent work has built on this study to show that the addition of CBD in conjunction with THC leads to a 14% increase in motor performance and an increase in survival beyond the survival rates with THC alone. In Amyotrophic Lateral Sclerosis (ALS), THC has been shown to delay motor deterioration and increase long term survival. THC and CBD combinations also show therapeutic promise across a number of disease states for which there has been limited therapeutic breakthrough to date. They found that 1:1 THC-CBD extracts provided the most therapeutic relief across all categories. In the clinical trials phase of drug development, researchers examined the effects of THC, CBD, and combination extracts on sleep, pain control, and muscle spasms. ![]() The most recent research into THC:CBD ratios comes out of the pharmaceutical industry, specifically around the GW Pharmaceuticals‘ Sativex, which has a 1:1 ratio of THC and CBD. Modern Therapeutic Applications Of The Cannabinoid Ratio These results support the theory that CBD works to minimize some of the negative side effects of THC. They found that 73% of study participants reported a decreased feeling of being “high” when compared to THC alone.įollow-up studies have demonstrated that the combination of the two cannabinoids reduced users’ experiences of tachycardia (increased heart rate), gait instability, and difficulty in eye tracking exercises. Subjects reported more pleasurable effects and less anxiety with the combination of CBD and THC than they felt with THC alone.įurthermore, a group of scientists examined the effects of administering CBD at a dose six times that of THC. In this study, patients were given between 15-60mg of CBD in conjunction with 30mg of THC, and the effects were measured. However, research on the simultaneous use of THC:CBD is less robust – its origins can be traced to Brazil in the mid-1970s. “Subjects reported more pleasurable effects and less anxiety with the combination of CBD and THC than they felt with THC alone.” THC demonstrates analgesic, anti-emetic, and anti-inflammatory properties, whereas CBD possesses anti-psychotic, anti-seizure, and anti-anxiety properties. Research on the benefits of tetrahydrocannabinol (THC) and cannabidiol (CBD) in isolation is well established. THC and CBD: The Beginning Of A Beautiful Friendship While the ability to control cannabinoid ratios within your own medicine remains limited, the information provided here will hopefully give you some insight into the future of cannabis based therapy. ![]() Given the fact that tetrahydrocannabinol (THC) and cannabidiol (CBD) are the two most prominent chemical compounds in the cannabis plant, the vast majority of research to date has focused on the ratio of these two cannabinoids. But one question remains in minds of many medical cannabis patients: “what is the optimal ratio of cannabinoids for my needs?” The answer, like many questions in the world of medicine, is still being researched. In last week’s post we explored the entourage effect and how all the compounds within the cannabis plant work together to give the plant its therapeutic versatility.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |